Abcuro Founder Reports on the Role of KLRG1+ T cells in Primary Billiary Cholangitis

Abcuro co-founder Steven A Greenberg, MD and his collaborators have published results of studies on clinical samples in primary biliary cholangitis (PBC), titled “Cytotoxic KLRG1 Expressing Lymphocytes Invade Portal Tracts in Primary Biliary Cholangitis”. PBC is an autoimmune disease characterized by T cell infiltration and attack of bile ducts. A chronic disease with significant unmet need, the long-term effect of this autoimmune inflammation is hepatic fibrosis and liver failure. Based on gene expression data, liver biopsies, blood samples and clinical data, the study identified a significant increase in the number of KLRG1+ CD8 T cells in liver biosies in relation to disease severity. It furthermore linked the degree of KLRG1+ cells in liver portal tracts with a clinical trial surrogate biomarker, serum alkaline phosphatase. The study was published in the Journal of Autoimmunity, and can be found here: https://doi.org/10.1016/j.jaut.2019.06.004.

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