Advancing Programs in Autoimmunity and Cancer
Inclusion Body Myositis (IBM) – a refractory autoimmune disease with no treatment options
IBM is the most prevalent acquired myopathy in adults older than age fifty. The disease is characterized by progressive weakness and atrophy of the muscles especially those of the arms and the legs. IBM can progress to cause severe disability.
IBM is an autoimmune condition in which cytotoxic T cells attack muscle and lead to degeneration of the tissue. Muscle tissue from patients with IBM show the presence of highly differentiated cytotoxic T cells and human IBM disease tissue expression studies revealed that KLRG1 is differentially expressed on these cells.
ABC-008 is an anti-KLRG1 antibody capable of selectively depleting a subpopulation of cytotoxic T cells present in muscle tissue, removing the source of immune attack.